Male infertility, varicocele & azoospermia

Cared for by Dr William Akakpo

A male factor is involved in about half of couples who struggle to conceive, yet it is often assessed superficially. The work-up here is complete: semen parameters, hormones, genetics, imaging and clinical examination, so that a treatable cause is not missed. Varicocele, hormonal disorders, obstruction and previous surgery can all be addressed. Even in non-obstructive azoospermia — no sperm at all in the ejaculate — microsurgical testicular sperm extraction recovers usable sperm in around half of men. Surgery is scheduled with the IVF laboratory so that retrieval and fertilisation happen on the same day.

Symptoms and reasons to consult

  • No pregnancy after twelve months of regular unprotected intercourse
  • Abnormal semen analysis: low count, poor motility or morphology
  • Azoospermia — no sperm found in the ejaculate
  • A soft swelling of the scrotum, worse on standing (varicocele)
  • Reduced testicular volume, low libido or gynaecomastia

How we assess it

  • Two semen analyses performed at an accredited laboratory
  • Hormonal profile: FSH, LH, testosterone, inhibin B, prolactin
  • Scrotal Doppler ultrasound and transrectal ultrasound when obstruction is suspected
  • Karyotype and Y-chromosome microdeletion testing, cystic fibrosis screening where indicated
  • Joint review with the fertility team and the partner's gynaecologist

Treatment options

Microsurgical varicocelectomy

Performed under the operating microscope through a small subinguinal incision, preserving the artery and lymphatics. Semen parameters improve in roughly two-thirds of men, and spontaneous pregnancy rates rise significantly.

Micro-TESE for non-obstructive azoospermia

The testis is opened under high magnification and the rare dilated seminiferous tubules that may contain sperm are identified individually. This maximises the retrieval rate while removing far less tissue than conventional biopsy.

MESA and TESA for obstructive azoospermia

Where production is normal but the pathway is blocked, sperm is retrieved directly from the epididymis or testis, with excellent yields and immediate use or freezing for ICSI.

Medical and hormonal treatment

Hypogonadotropic hypogonadism, hyperprolactinaemia and iatrogenic causes (including testosterone therapy) can often be corrected medically, sometimes restoring spermatogenesis without surgery.

Recovery and follow-up

  • Day-case surgery for varicocelectomy and sperm retrieval
  • Scrotal support and rest for 48 hours, mild discomfort for a week
  • Return to work after two to five days
  • Semen analysis at three and six months after varicocelectomy
  • Retrieved sperm used fresh with ICSI or frozen for later cycles

Frequently asked questions

What are the chances of finding sperm with micro-TESE?

Around 40 to 60% in non-obstructive azoospermia, depending on the cause, testicular histology and hormonal profile. The individual estimate is discussed before surgery.

Can everything be done during one stay in Paris?

Yes. The consultation, work-up, surgery and laboratory work are coordinated with the fertility centre so the couple's schedule stays as short as possible.

Does varicocele always need treating?

No. Treatment is offered when the varicocele is clinically palpable and associated with abnormal semen parameters, pain or testicular growth arrest.